With no clear benefits to researchers, a frustrating user experience, and no penalties for non-compliance, ClinicalTrials.gov is becoming increasingly irrelevant to clinical researchers and the world at large with each passing day. What does this mean for public access to research results? Is an obligation to patients putting themselves at risk in trials being breached? Why has it failed to live up to its potential?
Registering clinical trials after enrollment has commenced may lead to the perception that medical researchers are peeking.
Fewer than half of NIH sponsored clinical trials are published within 30 months, and 4 out of 5 FDA trials fail to publicly register results (as mandated by law), studies published in the BMJ report. Authors and sponsors may be the strongest source of reporting bias.