A fascinating article in Publishers Weekly details changes in large print books and magazines, enabled by the broad utilization of XML and more custom and e-publishing options.
One of the groups profiled is ReadHowYouWant. Not only are new type sizes and options available, but Braille and audio versions can be created, as well.
A PDF posted at the New York Times shows some interesting typographic options. My favorite is featured below. I think this is both funny and useful. Read the text to see if you agree.
With eye-strain a reality for everyone staring at computer monitors, and age an undeniable reality, these options show that computing technology has myriad uses for the creative and customer-focused.